Biotech founder Bryan Johnson reversed his age by 5.1 years

Biotech founder Bryan Johnson reversed his age

Blueprint is a project on reversing the age and was announced by an American entrepreneur, venture capitalist, writer and author, Bryan Johnson. The project started on October 13, 2021. The blueprint aims at quantifying and then maximally reversing the quantified biological age of his own organs. Johnson and his doctors claim that the project has so far resulted in an epigenetic age reversal of 5.1 years. As a result of the blueprint routine, Johnson is 47 years old have recorded the age of 42.5 years. Here’s how Biotech founder Bryan Johnson reversed his age by 5.1 years in 7 months.

Bryan Johnson spent $2 million a year to have a body of an 18-year-old and even succeeded in reversing 5.1 years of his age as per his doctors. Of course, he has to follow a strict daily routine and diet with a routine check of his vitals and changes. Although being a slow process, the blueprint is being speculated to bring over the scientific revolution.  However, it is dangerous to reverse the ageing process.

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Biotech founder Bryan Johnson reversed his age by 5.1 years in 7 months.  Here's how | Mint


Epigenetic clocks are mathematically derived age estimators that are based on combinations of methylation values that change with age. These clocks are widely useful in the measurement of the age of tissues and cells. Therefore, epigenetic age is a biomarker of ageing previously reported to be associated with age-related diseases and all-cause mortality. Re-engaging in healthy nutrition and lifestyle for 8 weeks may improve your epigenetic age by roughly 3 years.

There are several lifestyle factors that can modify epigenetic patterns. These factors include diet, obesity, physical activity, tobacco smoking, alcohol consumption, psychological stress and working on night shifts. Rather than determining our life span genetically, we determine it epigenetically. Diet and other environmental factors can influence our life span by changing epigenetic information. Also, the inhibitors of epigenetic enzymes can influence the life span of the model organism.

BLUEPRINT PROJECT-Biotech founder Bryan Johnson reversed his age

Johnson revealed the results of the blueprint after following it for nine months. It can be seen from the figure given below that his :

  • His chronological age is 44 and his biological age is apparently 5 years younger.
  • NAD levels decrease from 42 years  to what  16 years should have
  • Heart rate is decreased to the heart rate of 37 years
  • WBCs from age of 54 to the age of 33
  • HRV from age of 55 to the age of 39
  • Skin age reduced  from 40 to 28
  • Oral health of 40 years old reduced to 35 years old

In the interest of fine-tuning this program, Johnson constantly monitors his vital signs. Each month, he also endures dozens of medical procedures, some quite extreme and painful.

Biotech founder Bryan Johnson reversed his age by 5.1 years in 7 months

Graph or results of blueprint after nine months. Image source:



Despite the massive success of Braintree, John was overweight with stress and deeply depressed due to long hours. Finally, he tried to sort himself out and started learning more about his biology. Johnson earned $800 million in 2013 for selling Braintree to eBay. With over 30 doctors and regenerative health experts monitoring his every bodily function to reduce his biological age, Johnson follows a strict diet and routine. Johnson’s team is led by Oliver Zolman, a 29-year-old regenerative medicine physician. Johnson’s obsession with youth is the result of scientific literature on ageing and longevity as well as will power to discipline himself. Let’s understand the story behind how Biotech founder Bryan Johnson reversed his age.

He wants to have the brain, heart, lungs, liver, kidneys, tendons, teeth, skin, hair, bladder, penis and rectum of an 18-year-old. Obviously, to reverse the natural process without altering hormones and genes, Johnson sticks to strict guidelines. To keep track of his health Johnson undergoes numerous blood tests, ultrasounds and MRIs. This year he spent $2 million on his body.

According to Bryan Johnson, after following a blueprint for such a long time, he is now eating only what his body requires. However, there are some obvious signs that Johnson is at least healthier than most 45-year-olds. His body fat hovers between 5% and 6%, which leaves his muscles and veins on full display. But the internal changes in his body are something that excites his doctors the most. They say his tests show that he succeeded in reducing his overall biological age by at least five years. Their results suggest he has the heart of a 37-year-old, the skin of a 28-year-old and the lung capacity and fitness of an 18-year-old.


  • Weight, Body fat, Muscle mass, Body water, BMI
  • Sleep, HR, HRV, Respiration rate, Body temperature
  • Blood glucose
  • MRI- whole body
  • Ultrasound- whole body
  • Biofluids (Blood, Stool, Urine, Saliva)
  • Hearing
  • Eyes
  • Air Quality


Let’s find out how Biotech founder Bryan Johnson reversed his age. Bryan gets up at 5:30 a.m. and takes a concoction called the green giant and numerous supplements. He also follows a daily fitness routine and works out for an hour every single day. He does 25 different exercises and also regularly monitors his weight and body fat. In addition,  Johnson consumes only 1977 calories a day on a vegan diet. He even applies several creams on his face to reverse sun damage. He takes weekly acid peels and laser therapy. As a result of his strict routines and his willpower, he started to become biologically younger.

Zolman believes that progress in the field of longevity requires a more concerted pursuit of medicines and therapies that seem in any way promising. Since there is no person in the world who is 45 chronologically but 35 in every organ but if it is eventually possible to prove clinically and statistically that Bryan has made that change, then it will be such a large effect size that it will have to be causative of the intervention and beyond what’s genetically possible.

The whole project requires consistency and anything taken to the extreme like exercise, supplements and changes to diet can potentially lead to harmful effects on the body. For example, Zolman mentioned that at one point, Johnson’s body fat fell to 3 per cent which threatened the healthy functioning of his heart. So, to overcome this, his team recommended tweaks to his diet to include eating more throughout the day instead of taking up all the calories only once at breakfast. However, this irregularity or disturbance in his diet led to some allergic reactions and Johnson was swollen up.

Although, Johnson and Zolman, claim the blueprint to be a sort of success in decreasing epigenetic age by 5.1 years. It’s better to conclude that the future holds how revolutionary and helpful, the blueprint will become.

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Team MBD




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